High levels of city pollution linked to brain damage in children

The study involved 4,134 people (average age 59) who worked at the French national gas and electric company, of whom most worked at the company for their entire career. Their lifetime exposure to chlorinated solvents, petroleum solvents, benzene and non-benzene aromatic solvents was estimated, and they were given the Digit Symbol Substitution Test to assess cognitive performance. Cognitive impairment was defined as scoring below the 25th percentile. Most of the participants (88%) were retired.

Data from the Nurses' Health Study Cognitive Cohort, involving 19,409 older women (70-81), has found that higher levels of long-term exposure to air pollution were associated with faster rates of cognitive decline over a four-year period.

For each 10 micrograms per cubic meter of air increase in pollutants, cognitive decline was comparable to two years of age-related decline.

Pollution exposure was estimated from geography. Cognition was tested by three telephone interviews, administered at roughly two-year intervals.

So-called ‘Gulf War syndrome’ is a poorly understood chronic condition associated with exposure to neurotoxic chemicals and nerve gas, and despite its name is associated with three main syndromes: impaired cognition (syndrome 1); confusion-ataxia (syndrome 2); central neuropathic pain (syndrome 3). Those with syndrome 2 are the most severely affected. Note that the use of the term ‘impaired cognition’ for syndrome 1 is not meant to indicate that the other syndromes show no impaired cognition; rather, it signals the absence of other primary symptoms such as ataxia and pain.

In the first mouse study, when young and old mice were conjoined, allowing blood to flow between the two, the young mice showed a decrease in neurogenesis while the old mice showed an increase. When blood plasma was then taken from old mice and injected into young mice, there was a similar decrease in neurogenesis, and impairments in memory and learning.

Following several recent studies pointing to the negative effect of air pollution on children’s cognitive performance (see this April 2010 news report and this May 2011 report), a study of public schools in Michigan has found that 62.5% of the 3660 schools in the state are located in areas with high levels of industrial pollution, and those in areas with the highest industrial air pollution levels had the lo

A study in which mice were exposed to polluted air for three 5-hour sessions a week for 10 weeks, has revealed that such exposure damaged neurons in the hippocampus and caused inflammation in the brain. The polluted air was laden with particles collected from an urban freeway.

Increased awareness and changes in diagnostic criteria can’t entirely explain the massive increase in autism — the U.S. Centers for Disease Control reported a 57% increase between 2002 and 2006. Another factor may involve environmental pollutants.

Manganese exposure in the workplace is known to have neurotoxic effects, but manganese occurs naturally in soil and sometimes in groundwater. One region where the groundwater contains naturally high levels of manganese is Quebec. A study involving 362 Quebec children, aged 6-13, has measured both the concentrations of metals (manganese, iron, copper, lead, zinc, arsenic, magnesium and calcium) in their tap water, and their cognitive abilities.

A study following over 300 Mexican-American children living in an agricultural community has found that their prenatal exposure to organophosphate pesticides (measured by metabolites in the mother’s urine during pregnancy) was significantly associated with attention problems at age 5. This association was stronger among boys, and stronger with age (at 3 ½ the association, although present, did not reach statistical significance — perhaps because attention disorders are much harder to recognize in toddlers).

A five-year study involving 214 children born to healthy, non-smoking Caucasian women in Krakow, Poland, has found that those prenatally exposed to high levels of polycyclic aromatic hydrocarbons (PAHs) had a significant reduction in scores on a standardized test of reasoning ability and intelligence at age 5 (an estimated average decrease of 3.8 IQ points). The mothers wore small backpack personal air monitors for 48 hours during pregnancy to estimate their babies' PAH exposure.