Data from a 35-year study of women from Gothenburg in Sweden has revealed that the risk of dementia was about 65% higher in women who reported repeated periods of stress in middle age than in those who did not. The risk increased with number of periods of stress, with women who reported stress on all three occasions they were asked (1968, 1974 and 1980) having more than double the risk of dementia. Stress was defined as a sense of irritation, tension, nervousness, anxiety, fear or sleeping problems lasting a month or more due to work, health, family or other problems. Of the 1462 women in the sample used, 11% developed dementia, 65% of which was Alzheimer’s and 25% vascular dementia.
Stress in middle age could contribute to later dementia
Related News
Chronic stress heightens vulnerability to diet-related metabolic risk
A study involving 61 women, of whom 33 were chronically stressed caring for a spouse or parent with dementia, has found that highly stressed people who ate a lot of high-fat, high-sugar food were likely to have:
- a larger waistline,
- more truncal fat,
- higher oxidative damage, and
- more insulin resistance.
This association was not found among the low-stress women who ate the same amount of unhealthy food.
The findings are consistent with animal studies.
Negative social interactions increase hypertension risk in older women
A four-year study involving 1,502 healthy older adults (50+) has found that the frequency of negative interactions with family members (not partners or children) and friends was associated with an increased risk of developing hypertension in women (but not in men). Each increase in the total average negative social interaction score was associated with a 38% increased chance of developing hypertension. Younger older women (51-64) were more affected than those 65 or older.
Alzheimer's gene linked to red wine component
A new discovery helps explain why the “Alzheimer’s gene” ApoE4 is such a risk factor. It appears that ApoE4 causes a dramatic reduction in SirT1, an "anti-aging protein" that is targeted by resveratrol (present in red wine). This reduction in SirT1 was associated with a change in the way the amyloid precursor protein (APP) was processed. Moreover, there was evidence that ‘bad’ tau and amyloid-beta could be prevented by increasing SirT1.
http://www.eurekalert.org/pub_releases/2013-10/bifa-mar101613.php
Importance of vascular factors in Alzheimer's disease
Analysis of 5715 cases from the National Alzheimer's Coordinating Center (NACC) database has found that nearly 80% of more than 4600 Alzheimer's disease patients showed some degree of vascular pathology, compared with 67% of the controls, and 66% in the Parkinson's group. The link was especially strong for younger patients with Alzheimer’s.
No evidence of Alzheimer’s pathology in younger carriers of Alzheimer’s gene
Two studies indicate that young people carrying the “Alzheimer’s gene” (ApoE4) do not have the pathological changes found later in life. The first study, involving 1412 adolescents, found no differences in hippocampal volume or asymmetry as a function of gene status. The second study, involving 173 young adults (average age, 28 ± 7.6 years), found no difference in plasma concentrations of amyloid-beta peptides.
http://www.eurekalert.org/pub_releases/2014-04/ip-neo040614.php
Genes involved in familial Alzheimer's disease
Understanding a protein's role in familial Alzheimer's disease
Genetic engineering of human induced pluripotent stem cells has revealed very specifically how a key mutated protein is involved in familial Alzheimer's. Familial Alzheimer’s is a subset of early-onset Alzheimer's disease that is caused by inherited gene mutations.
COPD associated with increased risk of MCI
Data from 1,425 cognitively healthy older adults (70-89) has found that a diagnosis of chronic obstructive pulmonary disease (COPD) was associated with an 83% greater risk of developing non-amnestic mild cognitive impairment. The greatest risk was among patients who had COPD for more than five years.
Over the study period, 230 (16%) developed amnestic MCI, 97 (7%) nonamnestic MCI, 27 (2%) MCI of unknown type, and 16 dementia (1%).
Gum disease may have ties to Alzheimer’s
Analysis of post-mortem with and without dementia has found lipopolysaccharide, a component of an oral bacterium (Porphyromonas gingivalis), in four out of 10 Alzheimer’s disease brain samples, but not in any of the 10 brains of people who didn’t have Alzheimer’s.
Gingivitis is extremely common, and about 64% of American seniors (65+) have moderate or severe periodontal disease.
The finding adds to evidence linking gum disease and Alzheimer’s.
Tau tangles why TBI increases risk of Alzheimer's
We know that traumatic brain injury increases the risk of later developing neurodegenerative disorders such as Alzheimer's disease, but we haven't known why. New mouse studies suggest a reason.
Population study confirms link between traumatic brain injury and dementia
A review of nearly 2.8 million patient cases in Denmark found that the risk of dementia in individuals with a history of TBI was 24% higher than those without a history of TBI, after accounting for other risk factors.
Risk was greater when the TBI was characterized as "severe" — 35% compared to an increased risk of 17% for a single "mild" TBI or concussion.
Moreover, dementia risk increased 33% higher for two or three TBIs, 61% higher for four TBIs, and 183% higher for five or more TBIs.
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