Inflammation

A small clinical trial involving 49 older adults (average age 66) found that the group who were given a standardized mindfulness meditation program had greater improvement in sleep score than the group given a sleep hygiene education program. They also showed greater improvement on secondary measures of insomnia symptoms, depression symptoms, fatigue interference and fatigue severity. However, differences between the groups were not seen for anxiety, stress or inflammatory signaling, the last of which declined in both groups.

http://www.eurekalert.org/pub_releases/2015-02/tjnj-mma021215.php

Black DS, O’Reilly GA, Olmstead R, Breen EC, Irwin MR. Mindfulness Meditation and Improvement in Sleep Quality and Daytime Impairment Among Older Adults With Sleep Disturbances: A Randomized Clinical Trial. JAMA Intern Med. 2015;175(4):494-501. doi:10.1001/jamainternmed.2014.8081.

Two experiments involving more than 200 young adults have indicated that the extent to which they experienced positive emotions (such as amusement, awe, compassion, contentment, joy, love and pride) was linked to lower levels of pro-inflammatory cytokines. In particular, awe, wonder and amazement, were associated with the lowest levels of the cytokine, Interleukin 6 (a marker of inflammation).

High levels of cytokines are associated with poorer health and such disorders as type 2 diabetes, heart disease, arthritis, and even Alzheimer’s disease and clinical depression.

It's suggested that awe is associated with curiosity and a desire to explore, behaviors which are the opposite of those found during inflammation, where individuals typically withdraw from others.

http://www.eurekalert.org/pub_releases/2015-02/uoc--ana020315.php

Stellar, J. E., John-Henderson, N., Anderson, C. L., Gordon, A. M., McNeil, G. D., & Keltner, D. (2015). Positive affect and markers of inflammation: Discrete positive emotions predict lower levels of inflammatory cytokines. Emotion, 15(2), 129–133. http://doi.org/10.1037/emo0000033

Anecdotal and scientific evidence suggests curcumin, a compound found in turmeric, promotes health because it lowers inflammation. However, it is not absorbed well by the body. Most curcumin in food or supplements stays in the gastrointestinal tract, and any portion that's absorbed is metabolized quickly.

A new study thinks they've come up with a better and more effective way to deliver curcumin, and in so doing has demonstrated how it works. Curcumin powder was mixed with castor oil and polyethylene glycol, allowing it to dissolve and be more easily absorbed by the gut to enter the bloodstream and tissues.

When this was given to mice who had been injected with an extract that stimulates an immune reaction, a key protein that triggers an immune response was blocked. The mice given plain curcumin, on the other hand, showed the same protein actively triggering an immune response.

The emulsified curcumin also stopped recruitment of macrophages. Inflammation triggered by overactive macrophages has been linked to cardiovascular disease, disorders that accompany obesity, Crohn's disease, rheumatoid arthritis, inflammatory bowel disease, diabetes and lupus-related nephritis.

http://www.eurekalert.org/pub_releases/2014-11/osu-nra110614.php

A rat study has demonstrated that cytokines (immune system signaling molecules) impair communication among neurons in the hippocampus. The increased cytokine levels affected complex discrimination memory, that is, the ability to differentiate among generally similar experiences.

In the study, the rats were exposed to two similar environments, one of which was associated with a mild foot shock, making them reluctant to enter that environment. When some rats were then given a low dose of a bacterial agent to induce a neuroinflammatory response, leading to cytokine release in the brain, they became no longer able to distinguish between the two environments.

Analysis of changes in the activity patterns of hippocampal neurons suggested that cytokines impaired recall by disrupting the function of specific neuron circuits, taking the neural network that had learned the discrimination back to the state it had been before learning took place.

The finding may help explain "chemobrain", and suggests that an intervention aimed at reducing inflammation might be effective approach.

http://www.eurekalert.org/pub_releases/2014-09/uoc--bid091114.php

Czerniawski, J., & Guzowski, J. F. (2014). Acute Neuroinflammation Impairs Context Discrimination Memory and Disrupts Pattern Separation Processes in Hippocampus. The Journal of Neuroscience, 34(37), 12470–12480. http://doi.org/10.1523/JNEUROSCI.0542-14.2014

Here are some nut studies that link to benefits in connection with diabetes, heart disease, and inflammation. However, it should be noted that they are often very small, and usually funded by nut organizations. I wouldn't put too much weight on such.

Nuts linked to improved type 2 diabetes health

A 3-month study involving 117 older adults (mean age 62) with diabetes found that 75g of nuts (½ a cup) a day, as a replacement for carbohydrate foods, can improve glycemic control and blood lipids in those with type 2 diabetes.

The nuts used were a mixed lot of tree nuts (almonds, Brazils, cashews, hazelnuts, pecans, pine nuts, pistachios, macadamias and walnuts) and peanuts. improved blood lipid levels and blood sugar levels in individuals with non-insulin dependent diabetes.

https://www.eurekalert.org/pub_releases/2018-05/mp-itn052218.php

Jenkins, D.J.A., C.W.C. Kendall, B. Lamarche, M.S. Banach, K. Srichaikul, E. Vidgen, S. Mitchell, T. Parker, S. Nishi, B. Bashyam, R. de Souza, C. Ireland, S.C. Pichika, J. Beyene, J.L. Sievenpiper, R.G. Josse, 2018. Nuts as a replacement for carbohydrates in the diabetic diet: a reanalysis of a randomised controlled trial. Diabetologia https://doi.org/10.1007/s00125-018-4628-9

Eating pecans had significant effect on biomarkers of heart disease and type 2 diabetes

A very small 4-week study involving 26 overweight and obese adults (average age 59) found that those given a diet with pecans substituted for 15% of the total calories significantly improved insulin sensitivity and had a significant effect on markers of cardiometabolic disease.

Both the control diet and the pecan-rich diet were low in fruits, vegetables and fiber.

https://www.eurekalert.org/pub_releases/2018-03/kc-n-eph032218.php

The study entitled "A Pecan-Rich Diet Improves Cardiometabolic Risk Factors in Overweight and Obese Adults: A Randomized Controlled Trial" is available online and was presented at the American Society for Nutrition Annual Conference, Nutrition 2018 held in Boston in June.

A handful of nuts a day cuts the risk of a wide range of diseases

A review of 29 studies involving some 819,000 participants has concluded that people who eat at least 20g of nuts (a handful) a day have a 30% lower risk of heart disease, as well as lower risks of cancer, respiratory disease, and diabetes.

The study included all kinds of tree nuts, and also peanuts. The results were in general similar. There was little evidence of further improvement in health outcomes as a result of eating more than 20g of nuts.

Nuts and peanuts are high in fibre, magnesium, and polyunsaturated fats. Some nuts, particularly walnuts and pecan nuts are also high in antioxidants.

https://www.eurekalert.org/pub_releases/2016-12/icl-aho120216.php

Link between nut intake and inflammatory biomarkers

Data from 5,013 men and women participating in the Nurses' Health Study and Health Professionals Follow-up Study has revealed that higher nut intake (5 or more times per week) was associated with lower levels of inflammatory biomarkers (C-reactive protein (CRP) and Interleukin 6 (IL6)).

Research has also shown that nut consumption may be inversely related to body mass index (BMI), which is a strong determinant of inflammatory biomarkers, so it may be that the associations between nut intake and inflammatory markers are mediated in part through BMI.

http://www.eurekalert.org/pub_releases/2016-07/mp-itn072716.php

A study measuring the levels of the six most common carotenoids in blood from 193 patients with coronary artery disease has found that lutein was the only carotenoid whose level was correlated with the inflammatory marker interleukin-6, IL-6. The higher the level of lutein in the blood, the lower the level of IL-6.

Cells taken from blood from patients with coronary artery disease confirmed that the inflammatory activity of the cells became significantly lower when they were treated with lutein.

Lutein is found in several highly coloured vegetables and fruits, and is particularly rich in vegetables with dark-green leaves, such as spinach.

https://www.eurekalert.org/pub_releases/2017-07/lu-vca070517.php

Chung, Rosanna W.S., Leanderson, Per, Lundberg, Anna K, Jonasson, Lena. 2017. Lutein exerts anti-inflammatory effects in patients with coronary artery disease. Atherosclerosis, 262, 87-93, published online 6 May 2017, doi: 10.1016/j.atherosclerosis.2017.05.008