Severe, rapid memory loss linked to future, fatal strokes

March, 2012

A large, long-running study has revealed that older adults who suffered a fatal stroke showed significantly faster cognitive decline in the years preceding the stroke compared to stroke survivors and stroke-free adults.

A ten-year study following 12,412 middle-aged and older adults (50+) has found that those who died after stroke had more severe memory loss in the years before stroke compared to those who survived stroke and those who didn't have a stroke.

Participants were tested every two years, using a standard word-recall list to measure memory loss (or caregiver assessment for those whose memory loss was too severe). During the decade of the study, 1,027 participants (8.3%) survived a stroke, 499 (4%) died after stroke, and 10,886 (87.7%) remained stroke-free over the study period.

Before having a stroke, those who later survived a stroke had worse average memory than similar individuals who never had a stroke, however their rate of memory decline was similar (0.034 and 0.028 points per year, respectively). Those who later died after a stroke, on the other hand, showed significantly faster memory decline (0.118 points per year).

Whether this is because those who die after stroke have a more compromised brain prior to the stroke, or because greater memory impairment makes people more vulnerable in the wake of a stroke, cannot be told from this data (and indeed, both factors may be involved).

Among survivors, stroke had a significant effect on memory decline, with memory scores dropping an average of 0.157 points at the time of the stroke — an amount equivalent to around 5.6 years of memory decline in similarly-aged stroke-free adults. However, in subsequent years, decline was only a little greater than it had been prior to the stroke (0.038 points per year).

(You can see a nice graph of these points here.)

Reference: 

Wang, Q., Capistrant, B.D., Ehntholt, A. & Glymour, M.M. 2012. Abstract 31: Rate of Change in Memory Functioning Before and After Stroke Onset. Presented at the American Stroke Association's International Stroke Conference 2012. http://stroke.ahajournals.org/cgi/content/meeting_abstract/43/2_MeetingAbstracts/A31?sid=960f2015-06d1-478f-8c03-c00994d35f2c

Related News

Most of the (few) approved Alzheimer’s drugs are

We know that the E4 variant of the APOE gene greatly increases the risk of developing Alzheimer’s disease, but the reason is a little more mysterious. It has been thought that it makes it easier for amyloid plaques to form because it produces a protein that binds to amyloid beta.

I’ve talked before about the evidence linking diabetes to an increased risk of Alzheimer’s disease, but now a new study suggests that elevated blood sugar levels increase Alzheimer’s risk even in those without diabetes, even in those without ‘pre-diabetes’.

Evidence is accumulating that age-related cognitive decline is rooted in three related factors: processing speed slows down (because of myelin<

A study involving nearly 6,000 African American older adults has found those with a specific gene variant have almost double the risk of developing late-onset Alzheimer’s disease compared with African Americans who lack the variant.

Analysis of data from 418 older adults (70+) has found that carriers of the ‘Alzheimer’s gene’, APOEe4, were 58% more likely to develop mild cognitive impairment compared to non-carriers.

Analysis of eight studies on diet and stroke published between 1990 and 2012 has found that risk of first-time stroke dropped with every 7g increase in total daily fibre. That amount of fibre is contained in a bowl of wholewheat pasta plus two servings of fruit or vegetables.

A 2-year trial involving 251 patients with Parkinson's disease and early motor complications (mean age, 52 years; mean duration of disease, 7.5 years) has found that those given deep brain stimulation surgery significantly improved their quality of life, motor disability, activities of daily

Brain scans of 61 older adults (65-90), of whom 30 were cognitively healthy, 24 cognitively impaired and 7 diagnosed with dementia, found that, across all groups, both memory and executive function correlated negatively with brain infarcts, many of which had been clinically silent.

A small study of “Super Agers” has found a key difference between them and typical older adults: an unusually large

Pages

Subscribe to Latest newsSubscribe to Latest newsSubscribe to Latest health newsSubscribe to Latest news