We know that the E4 variant of the APOE gene greatly increases the risk of developing Alzheimer’s disease, but the reason is a little more mysterious. It has been thought that it makes it easier for amyloid plaques to form because it produces a protein that binds to amyloid beta. However, a new study shows that APOE and amyloid beta don’t bind together in cerebrospinal fluid and in fluids present outside cells grown in dishes, making it unlikely that they are binding together in the brain.
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Family caregivers of dementia sufferers who are reluctant to use adult day care services might like to note the findings of a telephone survey. The study involved eight daily telephone interviews on consecutive days with 173 family caregivers who use an ADS on some days.
We talk about memory for ‘events’, but how does the brain decide what an event is? How does it decide what is part of an event and what isn’t? A new study suggests that our brain uses categories it creates based on temporal relationships between people, objects, and actions — i.e., items that tend to—or tend not to—pop up near one another at specific times.
Most of the (few) approved Alzheimer’s drugs are cholinesterase inhibitors — that is, they stop the breakdown of the neurotransmitter acetylcholine. A new study explains why they help. It appears they allow signals to enter the brain with more precision and less background noise.
A new study adds to growing evidence of a link between sleep problems and Alzheimer’s. The interesting thing is that this association – between sleep apnea and Alzheimer’s biomarkers — wasn’t revealed until the data was separated out according to BMI.
Three classroom experiments have found that students who meditated before a psychology lecture scored better on a quiz that followed than students who did not meditate. Mood, relaxation, and class interest were not affected by the meditation training.
The noteworthy thing is that the meditation was very very basic — six minutes of written meditation exercises.
The effect was stronger in classes where more freshmen students were enrolled, suggesting that the greatest benefit is to those students who have most difficulty in concentrating (who are more likely to drop out).
Because long-term cognitive decline can occur in some older adults after undergoing surgery, there has been some concern that exposure to anesthesia may be associated with increased dementia risk. It is therefore pleasing to report that data from the very large, long-running Mayo Clinic Study, the Rochester Epidemiology Project, has found that receiving general anesthesia for procedures after age 45 is not a risk factor for developing dementia.
A recent study reveals that when we focus on searching for something, regions across the brain are pulled into the search. The study sheds light on how attention works.
In the experiments, brain activity was recorded as participants searched for people or vehicles in movie clips. Computational models showed how each of the roughly 50,000 locations near the cortex responded to each of the 935 categories of objects and actions seen in the movie clips.
Late-life depression is associated with an increased risk for all-cause dementia, Alzheimer’s disease, and, most predominantly, vascular dementia, a new study shows.
A new meta-analysis extends previous research showing a link between depression and Alzheimer’s disease to late-life depression and dementia. The analysis of 23 studies concluded that those with late-life depression were significantly more likely to develop dementia (1.85 times more likely), and that the risk of developing vascular dementia was significantly greater than that of developing Alzheimer’s (2.52 vs 1.65).
A recent report from Autistica estimates that nearly a quarter (24%) of children with autism are non-verbal or minimally verbal — problems that can persist into adulthood.
A review of over 200 published papers and more than 60 different intervention studies has now concluded that: