Latest Research News

A study involving nearly 6,000 African American older adults has found those with a specific gene variant have almost double the risk of developing late-onset Alzheimer’s disease compared with African Americans who lack the variant. The size of the effect is comparable to that of the ‘Alzheimer’s gene’, APOE-e4.

The gene (ABCA7) is involved in the production of cholesterol and lipids. It also affects the transport of several important proteins, including amyloid precursor protein, which is involved in the production of amyloid-beta.

Analysis of data from 418 older adults (70+) has found that carriers of the ‘Alzheimer’s gene’, APOEe4, were 58% more likely to develop mild cognitive impairment compared to non-carriers. However, ε4 carriers with MCI developed Alzheimer’s at the same rate as non-carriers. The finding turns prevailing thinking on its head: rather than the gene increasing the risk of developing Alzheimer’s, it appears that it increases the risk of MCI — and people with MCI are the main source of new Alzheimer’s diagnoses.

A study has found that brain regions responsible for making decisions continue to be active even when the conscious brain is distracted with a different task.

The study, in which 27 adults were given information about cars and other consumer products then asked to perform a brief but challenging working memory task (involving numbers) before making their decision about the items, found that:

A study involving 97 infants, of whom 56 were at high risk of an autism spectrum disorder, has found that the high-risk infants later found to have ASD (only 16 of the 56) were slower to orient or shift their gaze (by approximately 50 milliseconds) than both high-risk-negative and low-risk infants. Moreover, visual orienting in low-risk infants was uniquely associated with a specific neural circuit (the splenium of the corpus callosum), but was not in those later classified with ASD.

Evidence is accumulating that age-related cognitive decline is rooted in three related factors: processing speed slows down (because of myelin degradation); the ability to inhibit distractions becomes impaired; working memory capacity is reduced.

A new study adds to this evidence by looking at one particular aspect of age-related cognitive decline: memory search.

A new study claims to provide ‘some of the strongest evidence yet’ for the benefits of gesturing to help students learn.

The study involved 184 children aged 7-10, of whom half were shown videos of an instructor teaching math problems using only speech, while the rest were shown videos of the instructor teaching the same problems using both speech and gestures. The problem involved mathematical equivalence (i.e., 4+5+7=__+7), which is known to be critical to later algebraic learning.

In the first study to analyze parent praise in a real-world setting, it’s been found that the kind of praise parents give their babies and toddlers influences the child’s motivation later on, and plays a role in children’s beliefs about themselves and their desire to take on challenges five years later.

A small study of “Super Agers” has found a key difference between them and typical older adults: an unusually large anterior cingulate (involved in attention), with four times as many von Economo neurons.

Scientific American article

Caffeine occurs naturally in the nectar of coffee and citrus flowers. A study of honeybees has revealed that those fed on caffeinated nectar were three times more likely to remember a flower's scent than bees fed sugar alone, after 24 hours. After three days, they were still twice as likely to remember the flower than those fed sugar alone.

A study involving 187 children and adolescents with multiple sclerosis, plus 44 who experienced their first neurologic episode (clinically isolated syndrome) indicative of MS, has found that 35% of those with MS and 18% of those with clinically isolated syndrome were cognitively impaired. Cognitive assessment was done using a battery of 11 tests. The most common areas of impairment were fine motor coordination, visual-motor integration, and speeded information processing.