Research

Analysis of data from 418 older adults (70+) has found that carriers of the ‘Alzheimer’s gene’, APOEe4, were 58% more likely to develop mild cognitive impairment compared to non-carriers. However, ε4 carriers with MCI developed Alzheimer’s at the same rate as non-carriers. The finding turns prevailing thinking on its head: rather than the gene increasing the risk of developing Alzheimer’s, it appears that it increases the risk of MCI — and people with MCI are the main source of new Alzheimer’s diagnoses.

A new finding points to brain reorganization, rather than brain size, as the driver in primate brain evolution. Data from 17 anthropoid primate species (including humans) across 40 million years has found that around three quarters of differences between the brains of species of monkeys and apes are due to internal reorganization that is independent of size. The prefrontal cortex in particular appears to have played the biggest role in explaining the evolutionary changes in primate brains.

http://phys.org/news/2013-03-organisation-trumps-size-primate-brain.html

Analysis of eight studies on diet and stroke published between 1990 and 2012 has found that risk of first-time stroke dropped with every 7g increase in total daily fibre. That amount of fibre is contained in a bowl of wholewheat pasta plus two servings of fruit or vegetables.

Insufficient data is available to say whether soluble or insoluble fibre is better. The studies came from the United States, northern Europe, Australia, and Japan.

Matching patterns of sales data for lottery games in one American county for a year against daily temperature has revealed that sales for scratch tickets (many options to select) fell by nearly $600 with every 1° Fahrenheit increase in temperature. On the other hand, sales for lotto tickets, which require fewer decisions, were not affected.

Caffeine occurs naturally in the nectar of coffee and citrus flowers. A study of honeybees has revealed that those fed on caffeinated nectar were three times more likely to remember a flower's scent than bees fed sugar alone, after 24 hours. After three days, they were still twice as likely to remember the flower than those fed sugar alone.

Data from the very large, long-running UK National Child Development Study has revealed that those who exercised at least four times weekly as both a child and an adult performed better on cognitive tests at age 50 than those who exercised two to three times per month or less, and the latter in turn performed better than those who hadn’t regularly exercised at all.

A 2-year trial involving 251 patients with Parkinson's disease and early motor complications (mean age, 52 years; mean duration of disease, 7.5 years) has found that those given deep brain stimulation surgery significantly improved their quality of life, motor disability, activities of daily living, levodopa-induced motor complications, and time with good mobility and no dyskinesia. Those given normal medical therapy, on the other hand, declined or at best got no worse.

More evidence for the importance of glia, previously regarded as mere ‘support cells’ in the brain, comes from a mouse study — which also indicates the role of astrocytes in the evolution of the human brain. The study found that mice that received transplants of human glial progenitor cells learned much more quickly than normal mice.

A study involving 520 intensive care patients who had been put on ventilators for acute lung injury (ALI), of whom 186 patients of the 275 survivors were followed up over the next two years, found that 35% of them had clinically significant symptoms of PTSD. Nearly two-thirds of these (62%) still had symptoms at two years.

ICU survivors with PTSD are unusual in that they often experience flashbacks to delusions or hallucinations they had in the hospital, rather than events that actually occurred

Brain scans of 61 older adults (65-90), of whom 30 were cognitively healthy, 24 cognitively impaired and 7 diagnosed with dementia, found that, across all groups, both memory and executive function correlated negatively with brain infarcts, many of which had been clinically silent. The level of amyloid in the brain did not correlate with either changes in memory or executive function, and there was no evidence that amyloid interacted with infarcts to impair thinking.