New advice on how much cognitive abilities decline with age

October, 2010

A new study suggests that inconsistencies in rate of age-related cognitive decline may be partly due to practice effects, but though decline does occur it is slower than some have estimated.

Reports on cognitive decline with age have, over the years, come out with two general findings: older adults do significantly worse than younger adults; older adults are just as good as younger adults. Part of the problem is that there are two different approaches to studying this, each with their own specific bias. You can keep testing the same group of people as they get older — the problem with this is that they get more and more practiced, which mitigates the effects of age. Or you can test different groups of people, comparing older with younger — but cohort differences (e.g., educational background) may disadvantage the older generations. There is also argument about when it starts. Some studies suggest we start declining in our 20s, others in our 60s.

One of my favorite cognitive aging researchers has now tried to find the true story using data from the Virginia Cognitive Aging Project involving nearly 3800 adults aged 18 to 97 tested on reasoning, spatial visualization, episodic memory, perceptual speed and vocabulary, with 1616 tested at least twice. This gave a nice pool for both cross-sectional and longitudinal comparison (retesting ranged from 1 to 8 years and averaged 2.5 years).

From this data, Salthouse has estimated the size of practice effects and found them to be as large as or larger than the annual cross-sectional differences, although they varied depending on the task and the participant’s age. In general the practice effect was greater for younger adults, possibly because younger people learn better.

Once the practice-related "bonus points" were removed, age trends were flattened, with much less positive changes occurring at younger ages, and slightly less negative changes occurring at older ages. This suggests that change in cognitive ability over an adult lifetime (ignoring the effects of experience) is smaller than we thought.

Reference: 

Related News

The latest finding from the large, long-running Health, Aging, and Body Composition (Health ABC) Study adds to the evidence that preventing or controlling diabetes helps prevent age-related cognitive decline.

A review of three high quality trials comparing the putative benefits of omega-3 fatty acids for preventing age-related cognitive decline, has concluded that there is no evidence that taking fish oil supplements helps fight cognitive decline.

While the ‘Alzheimer’s gene’ is relatively common — the ApoE4 mutation is present in around 15% of the population — having two copies of the mutation is, thankfully, much rarer, at around 2%.

Dementia is a progressive illness, and its behavioral and psychological symptoms are, for caregivers, the most difficult symptoms to manage.

A study designed to compare the relative benefits of exercise and diet control on Alzheimer’s pathology and cognitive performance has revealed that while both are beneficial, exercise is of greater benefit in reducing Alzheimer’s pathology and cognitive impairment.

I have reported previously on research suggesting that rapamycin, a bacterial product first isolated from soil on Easter Island and used to help transplant patients prevent organ rejection, might improve learning and memory.

Following on from mouse studies, a human study has investigated whether caffeine can help prevent older adults with mild cognitive impairment from progressing to dementia.

A study involving those with a strong genetic risk of developing Alzheimer’s has found that the first signs of the disease can be detected 25 years before symptoms are evident.

A number of studies have come out in recent years linking age-related cognitive decline and dementia risk to inflammation and infection (put inflammation into the “Search this site” box at the top of the page and you’ll see what I mean). New research suggests one important mechanism.

I’ve reported before on the evidence suggesting that carriers of the ‘Alzheimer’s gene’, APOE4, tend to have smaller brain volumes and perform worse on cognitive tests, despite being cognitively ‘normal’.

Pages

Subscribe to Latest newsSubscribe to Latest newsSubscribe to Latest health newsSubscribe to Latest news