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Alzheimer's & Dementia

Latest News

  • It seems clear now that a substantial decline in sense of smell is a very early sign of developing MCI and Alzheimer's.
  • Several tests have been developed to assess this.
  • It should always be remembered that there is substantial difference between individuals in their 'natural' sense of smell, and this needs to be taken into account in any test.

In the past few months, several studies have come out showing the value of three different tests of people's sense of smell for improving the accuracy of MCI and Alzheimer's diagnosis, or pointing to increased risk.

  • A short exercise program improved cognition and brain blood flow in older adults with mild cognitive impairment.

A small study has found that a 12-week exercise program significantly improved cognition in both older adults with MCI and those who were cognitively healthy, but that effect on blood flow in the brain was different in these two groups.

  • A study found an association in healthy older adults between higher amyloid beta levels and worsening anxiety.

Data from the Harvard Aging Brain Study found that higher amyloid beta levels were associated with increasing anxiety symptoms in cognitively normal older adults. The results suggest that worsening anxious-depressive symptoms may be an early predictor of elevated amyloid beta levels.

  • A rat brain cell study provides evidence that alcohol may increase Alzheimer's risk by impeding the removal of amyloid-beta protein.
  • A very large French study found that 38% of early-onset dementia cases were directly alcohol-related and 18% had an additional diagnosis of alcohol use disorders.

How alcohol increases Alzheimer's risk

A French study involving 36 healthy older adults (60-80), prescreened for amyloid deposits in the brain to exclude people who might have preclinical Alzheimer’s disease, has found a linear increase in gray matter volume in proportion to the number of years of education (7-20 years).

  • A finding that Alzheimer's sufferers' failure to recognize familiar faces is rooted in an impairment in holistic perception rather than memory loss, suggests new strategies to help patients recognize their loved ones for longer.

People with Alzheimer's disease develop problems in recognizing familiar faces. It has been thought that this is just part of their general impairment, but a new study indicates that a specific, face-related impairment develops early in the disease.

  • A very large genetic study provides evidence that cardiovascular disease risk and Alzheimer's risk are related because of one shared element: genes involved in cholesterol and lipid metabolism.

The APOE gene, the strongest genetic risk factor for Alzheimer’s disease, is known to be involved in cholesterol and lipid metabolism.

  • Blood flow deficits in the brain, seen early on in Alzheimer's, have now been linked to some capilleries being block by white blood cells.

It’s been known that decreased blood flow in the brain occurs in people with Alzheimer's, and recent studies suggest that brain blood flow deficits are one of the earliest detectable symptoms of dementia.

  • Studies involving genetically engineered mice found that canola oil was linked to worse cognition, more amyloid plaques, and greater synapse loss, while extra-virgin olive oil was linked to fewer plaques, less inflammation, and better memory.

A mouse study has found that canola oil in the diet was associated with worsened memory, worsened learning ability, and weight gain in Alzheimer's mice.

  • A long-running study involving women only found that regular exercise in middle age was the most effective they could do to prevent later cognitive decline.

A long-running study following 387 Australian women found that regular exercise in middle age was the best lifestyle change they could make to prevent cognitive decline in their later years.