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Alzheimer's & Dementia

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A French study involving 36 healthy older adults (60-80), prescreened for amyloid deposits in the brain to exclude people who might have preclinical Alzheimer’s disease, has found a linear increase in gray matter volume in proportion to the number of years of education (7-20 years).

  • A finding that Alzheimer's sufferers' failure to recognize familiar faces is rooted in an impairment in holistic perception rather than memory loss, suggests new strategies to help patients recognize their loved ones for longer.

People with Alzheimer's disease develop problems in recognizing familiar faces. It has been thought that this is just part of their general impairment, but a new study indicates that a specific, face-related impairment develops early in the disease.

  • A very large genetic study provides evidence that cardiovascular disease risk and Alzheimer's risk are related because of one shared element: genes involved in cholesterol and lipid metabolism.

The APOE gene, the strongest genetic risk factor for Alzheimer’s disease, is known to be involved in cholesterol and lipid metabolism.

  • Blood flow deficits in the brain, seen early on in Alzheimer's, have now been linked to some capilleries being block by white blood cells.

It’s been known that decreased blood flow in the brain occurs in people with Alzheimer's, and recent studies suggest that brain blood flow deficits are one of the earliest detectable symptoms of dementia.

  • Studies involving genetically engineered mice found that canola oil was linked to worse cognition, more amyloid plaques, and greater synapse loss, while extra-virgin olive oil was linked to fewer plaques, less inflammation, and better memory.

A mouse study has found that canola oil in the diet was associated with worsened memory, worsened learning ability, and weight gain in Alzheimer's mice.

  • A long-running study involving women only found that regular exercise in middle age was the most effective they could do to prevent later cognitive decline.

A long-running study following 387 Australian women found that regular exercise in middle age was the best lifestyle change they could make to prevent cognitive decline in their later years.

A new review from The Cochrane Library, based on six trials involving 289 people, has concluded that exercise can improve cognition and the ability of older people with dementia to carry out daily activities, such as walking short distances or getting up from a chair.

  • An easy new rating scale will help those with Lewy Body dementia be diagnosed much more quickly.

After Alzheimer's disease, the next most common type of dementia is Lewy Body disease. Far less widely known, this form of dementia is often diagnosed quite late.

  • A large study shows that the falling rates of dementia reflect later onset coupled with shorter time spent with the dementia.

A large study using data from the famous Framingham Heart Study has compared changes in dementia onset over the last three decades. The study found that over time the age of onset has increased while the length of time spent with dementia has decreased.

  • More evidence that Alzheimer's disease is not a single disease with a single cause and single pathway comes from a large study classifying patients into 6 groups, only two of which showed strong genetic association.
  • Another study using post-mortem brain tissue found that different genes were associated with different types of brain damage.

A study involving 4,050 people with late-onset Alzheimer's disease (mean age 80) has classified them into six groups based on their cognitive functioning at the time of diagnosis. A genetic study found two of the groups showed strong genetic associations.