Health

A large data set from Health Survey for England 1998-2008 was analyzed to determine the association between alcohol consumption and mortality for different age and gender groups.

Compared with never drinkers, protective associations were largely limited to:

• men aged 50-64 years who reported consuming 15-20 units on average per week or 0.1-1.5 units on the heaviest day
• women aged 65 and over who reported consuming 10 units or less on average per week and at all levels of heaviest day use.

Little to no protection was found in other age-sex groups, regardless of consumption level.

http://www.eurekalert.org/pub_releases/2015-02/bmj-cct020615.php

A review of 200 studies on depression and inflammation has concluded that depression and inflammation fuel one another, with inflammation playing a key role in the development of depression in some people, and depression priming greater physiological responses to stress.

Moreover, depression that is caused by chronic inflammation is resistant to traditional therapy methods. However, it is more responsive to activities such as yoga, meditation, omega-3 fatty acids, NSAIDS and exercise.

The review indicates that treatment for depression needs to consider its pathway. The researcher suggests that chronic inflammation is most common in individuals who have experienced stress in their lives, including lower socio-economic status or those who experienced abuse or neglect as children. Other contributing factors are a high-fat diet and high body mass index.

If inflammation is a significant factor, it needs to be treated in tandem with the depression.

http://www.eurekalert.org/pub_releases/2015-12/ru-icf121815.php

Kiecolt-Glaser, J. K., Derry, H. M., & Fagundes, C. P. (2015). Inflammation: Depression Fans the Flames and Feasts on the Heat. American Journal of Psychiatry, 172(11), 1075–1091. http://doi.org/10.1176/appi.ajp.2015.15020152

Stress, including sleep disturbance, is a major contributor to inflammation in the body. Insomnia is associated with increased risk for depression, medical comorbidities, and mortality.

A study involving 123 older adults (55+) with insomnia randomly assigned them to one of 3 types of classes: cognitive behavioral therapy for insomnia, tai chi, or a sleep seminar (the control condition).

Cognitive behavioral therapy for insomnia reduced insomnia symptoms and levels of the inflammation marker C-reactive protein, and reversed activation of molecular inflammatory signaling pathways. These benefits were maintained for 16 months.

Tai chi also reduced inflammation, reducing the expression of inflammation at the cellular level and reversing activation of inflammatory signaling pathways. It marginally reduced levels of C-reactive protein. Again, these benefits were maintained for 16 months.

Those participants assigned to the sleep seminar classes showed no significant changes in inflammatory markers, as expected.

http://www.eurekalert.org/pub_releases/2015-11/e-bsa110515.php

Irwin, M. R., Olmstead, R., Breen, E. C., Witarama, T., Carrillo, C., Sadeghi, N., … Cole, S. (2015). Cognitive Behavioral Therapy and Tai Chi Reverse Cellular and Genomic Markers of Inflammation in Late-Life Insomnia: A Randomized Controlled Trial. Biological Psychiatry, 78(10), 721–729. http://doi.org/10.1016/j.biopsych.2015.01.010

Two experiments involving more than 200 young adults have indicated that the extent to which they experienced positive emotions (such as amusement, awe, compassion, contentment, joy, love and pride) was linked to lower levels of pro-inflammatory cytokines. In particular, awe, wonder and amazement, were associated with the lowest levels of the cytokine, Interleukin 6 (a marker of inflammation).

High levels of cytokines are associated with poorer health and such disorders as type 2 diabetes, heart disease, arthritis, and even Alzheimer’s disease and clinical depression.

It's suggested that awe is associated with curiosity and a desire to explore, behaviors which are the opposite of those found during inflammation, where individuals typically withdraw from others.

http://www.eurekalert.org/pub_releases/2015-02/uoc--ana020315.php

Stellar, J. E., John-Henderson, N., Anderson, C. L., Gordon, A. M., McNeil, G. D., & Keltner, D. (2015). Positive affect and markers of inflammation: Discrete positive emotions predict lower levels of inflammatory cytokines. Emotion, 15(2), 129–133. http://doi.org/10.1037/emo0000033

A study has revealed that the immune system has a seasonal cycle, in which its activity is boosted during the winter and relaxes during the summer. While the winter increase in immune defences presumably helps us stave off infections, it also raises the risk of harmful inflammation, effectively lowering the threshold for heart attacks, stroke, diabetes and even some psychiatric conditions. This may explain why deaths from conditions ranging from heart attacks to diabetes and schizophrenia increase in winter.

The study used blood samples from more than 16,000 people living in both the northern and southern hemisphere

http://www.theguardian.com/science/2015/may/12/winter-immune-boost-may-actually-cause-deaths-study-suggests

Dopico, X. C., Evangelou, M., Ferreira, R. C., Guo, H., Pekalski, M. L., Smyth, D. J., … Todd, J. A. (2015). Widespread seasonal gene expression reveals annual differences in human immunity and physiology. Nature Communications, 6, 7000. http://doi.org/10.1038/ncomms8000

Following growing evidence that exposure to nature makes people feel and think better, a study using 3-D videos of residential streets with varying amounts of tree canopy has demonstrated a dose-response curve.

The study involved 80 men and 78 women, who were stressed by having to deliver five-minute impromptu speeches before two interviewers and a video camera, before then having to solve several subtraction problems out loud, without using computing devices, paper or pencil. Afterwards, they watched one of 10 panoramic 3-D videos showing similar neighborhood streets on which the density of tree cover ranged from 2 to 62%.

The men displayed a bell-shaped dose-response curve, with their stress biomarkers (salivary cortisol and skin conductance levels) improving steadily as the tree canopy increased from 2 to 24%. The greatest benefits came from tree canopy in the 24-34% range, and stress recovery declined for tree cover over 34%.

Women did not show the same physiological response, although their self-reports suggested that they also experienced stress reduction benefits that increased proportionally with the percentage of tree canopy viewed.

While 41% of male and female participants who watched videos with minimal tree canopy described calming effects, more than 90% reported feeling calm or relaxed when the tree canopy was at 36%. All reported well-being when the tree cover was at 62%.

http://medicalxpress.com/news/2014-10-d-videos-trees-people-recover.html

Jiang, B., Li, D., Larsen, L., & Sullivan, W. C. (2016). A Dose-Response Curve Describing the Relationship Between Urban Tree Cover Density and Self-Reported Stress Recovery. Environment and Behavior, 48(4), 607–629. http://doi.org/10.1177/0013916514552321

Anecdotal and scientific evidence suggests curcumin, a compound found in turmeric, promotes health because it lowers inflammation. However, it is not absorbed well by the body. Most curcumin in food or supplements stays in the gastrointestinal tract, and any portion that's absorbed is metabolized quickly.

A new study thinks they've come up with a better and more effective way to deliver curcumin, and in so doing has demonstrated how it works. Curcumin powder was mixed with castor oil and polyethylene glycol, allowing it to dissolve and be more easily absorbed by the gut to enter the bloodstream and tissues.

When this was given to mice who had been injected with an extract that stimulates an immune reaction, a key protein that triggers an immune response was blocked. The mice given plain curcumin, on the other hand, showed the same protein actively triggering an immune response.

The emulsified curcumin also stopped recruitment of macrophages. Inflammation triggered by overactive macrophages has been linked to cardiovascular disease, disorders that accompany obesity, Crohn's disease, rheumatoid arthritis, inflammatory bowel disease, diabetes and lupus-related nephritis.

http://www.eurekalert.org/pub_releases/2014-11/osu-nra110614.php

A rat study has demonstrated that cytokines (immune system signaling molecules) impair communication among neurons in the hippocampus. The increased cytokine levels affected complex discrimination memory, that is, the ability to differentiate among generally similar experiences.

In the study, the rats were exposed to two similar environments, one of which was associated with a mild foot shock, making them reluctant to enter that environment. When some rats were then given a low dose of a bacterial agent to induce a neuroinflammatory response, leading to cytokine release in the brain, they became no longer able to distinguish between the two environments.

Analysis of changes in the activity patterns of hippocampal neurons suggested that cytokines impaired recall by disrupting the function of specific neuron circuits, taking the neural network that had learned the discrimination back to the state it had been before learning took place.

The finding may help explain "chemobrain", and suggests that an intervention aimed at reducing inflammation might be effective approach.

http://www.eurekalert.org/pub_releases/2014-09/uoc--bid091114.php

Czerniawski, J., & Guzowski, J. F. (2014). Acute Neuroinflammation Impairs Context Discrimination Memory and Disrupts Pattern Separation Processes in Hippocampus. The Journal of Neuroscience, 34(37), 12470–12480. http://doi.org/10.1523/JNEUROSCI.0542-14.2014

Telomeres are the protective caps at the ends of chromosomes that affect how quickly cells age. With age, they shorten, and as their structural integrity weakens, the cells age and die quicker. Telomere length thus is a biomarker of cellular age. Stress is also thought to shorten telomere length.

A year-long study that looked at the effects of three healthy behaviors in 239 post-menopausal, non-smoking women has found that women who engaged in lower levels of healthy behaviors showed a significantly greater telomere shortening for every major life stressor that occurred. However, stress didn't lead to greater shortening in those women who maintained active lifestyles, healthy diets, and good quality sleep.

Shorter telomeres have become associated with a broad range of aging-related diseases, including stroke, vascular dementia, cardiovascular disease, obesity, osteoporosis diabetes, and many forms of cancer.

http://www.eurekalert.org/pub_releases/2014-07/uoc--hlm072414.php

Puterman, E., Lin, J., Krauss, J., Blackburn, E. H., & Epel, E. S. (2015). Determinants of telomere attrition over 1 year in healthy older women: stress and health behaviors matter. Molecular Psychiatry, 20(4), 529–535. http://doi.org/10.1038/mp.2014.70

A review of trials of interventions that sought to reduce sitting time has found the following strategies, among others, were 'promising':

• having sit-stand desks at work
• keeping records of your sitting time
• setting individual goals for limiting sitting time
• having prompts and cues to remind you to stop sitting
• learning about the health benefits of reducing sitting time
• getting feedback on your behavior
• restructuring your physical and social environment to support the behavior changes
• practising the new behavior
• working out how to solve any problems that arise from shifting to less sitting time
• having social support.

The researchers did note that the overall standard of the studies was poor, so we can't yet point to any clear strategy, but these provide a guide for action. They also noted that the more promising interventions involved a greater number of strategies — in other words, to be successful, you need to tackle this behavior change from a number of angles.

http://www.eurekalert.org/pub_releases/2015-09/kcl-sft092115.php

Gardner, B., Smith, L., Lorencatto, F., Hamer, M., & Biddle, S. J. (2016). How to reduce sitting time? A review of behaviour change strategies used in sedentary behaviour reduction interventions among adults. Health Psychology Review, 10(1), 89–112. http://doi.org/10.1080/17437199.2015.1082146