A three-year study involving 169 people with mild cognitive impairment has found that those who later developed Alzheimer's disease showed 10-30% greater atrophy in two specific locations within the hippocampus, the cornu ammonis (CA1) and the subiculum.
Latest Research News
Previous research has shown that older adults are more likely to incorrectly repeat an action in situations where a prospective memory task has become habitual — for example, taking more medication because they’ve forgotten they’ve already taken it. A new study has found that doing something unusual at the same time helps seniors remember having done the task. In the study, older adults told to put a hand on their heads whenever they made a particular response, reduced the level of repetition errors to that of younger adults.
A German study involving nearly 4000 older adults (55+) has found that physical activity significantly reduced the risk of developing mild cognitive impairment over a two-year period. Nearly 14% of those with no physical activity at the start of the study developed cognitive impairment, compared to 6.7% of those with moderate activity, and 5.1% of those with high activity. Moderate activity was defined as less than 3 times a week.
You may think that telling students to strive for excellence is always a good strategy, but it turns out that it is not quite as simple as that. A series of four experiments looking at how students' attitudes toward achievement influenced their performance on various tasks has found that while those with high achievement motivation did better on a task when they also were exposed to subconscious "priming" that related to winning, mastery or excellence, those with low achievement motivation did worse.
Part of the Women's Health Initiative study looking at the effect of hormone therapy on thinking and memory in postmenopausal women, involving over 1400 women, has found those who had high blood pressure at the start of the study (eight years earlier) had significantly higher amounts of white matter lesions. Damage to white matter seems to be an independent risk factor for dementia. The finding adds to evidence suggesting that preventing hypertension helps protect against dementia. High blood pressure is common in the U.S.
A study (“Midlife in the United States”) assessing 3,343 men and women aged 32-84 (mean age 56), of whom almost 40% had at least a 4-year college degree, has found evidence that frequent cognitive activity can counteract the detrimental effect of poor education on age-related cognitive decline.
Subjective cognitive impairment (SCI), marked by situations such as when a person recognizes they can't remember a name like they used to or where they recently placed important objects the way they used to, is experienced by between one-quarter and one-half of the population over the age of 65. A seven-year study involving 213 adults (mean age 67) has found that healthy older adults reporting SCI are dramatically more likely to progress to MCI or dementia than those free of SCI (54% vs 15%). Moreover, those who had SCI declined significantly faster.
A rat study has found that increased levels of magnesium in the brain improved many aspects of learning and memory in both young and old rats. Because it is difficult to boost brain magnesium levels with traditional oral supplements, the researchers developed a new magnesium compound, magnesium-L-threonate (MgT). The cognitive improvements were associated with an increase in synapses and improved synaptic plasticity.
No surprise to me (I’m hopeless at faces), but a twin study has found that face recognition is heritable, and that it is inherited separately from IQ. The findings provide support for a modular concept of the brain, suggesting that some cognitive abilities, like face recognition, are shaped by specialist genes rather than generalist genes. The study used 102 pairs of identical twins and 71 pairs of fraternal twins aged 7 to 19 from Beijing schools to calculate that 39% of the variance between individuals on a face recognition task is attributable to genetic effects.
It’s been suggested before that Down syndrome and Alzheimer's are connected. Similarly, there has been evidence for connections between diabetes and Alzheimer’s, and cardiovascular disease and Alzheimer’s. Now new evidence shows that all of these share a common disease mechanism. According to animal and cell-culture studies, it seems all Alzheimer's disease patients harbor some cells with three copies of chromosome 21, known as trisomy 21, instead of the usual two. Trisomy 21 is characteristic of all the cells in people with Down syndrome.